The Bicentennial Scenic Byway runs contiguously with the Trail of the Ancients National Scenic Byway for part of the route. It traverses a variety of ecosystems from desert to over 6,000 feet in elevation and includes pinion and juniper forest and desert canyons. Along the way it accesses Natural Bridges National Monument, Glen Canyon National Recreation Area, Grand Gulch Primitive Area, and a multitude of hiking and four wheeling canyons and mesas. Mule Canyon Ruin lies immediately adjacent to the road and is accessible to the physically challenged with a parking area which will accommodate motor homes and coaches, a pit toilet, and paved pathways to and around the ruin. A signboard is present at Mule Canyon which explains the Ancestral Puebloan culture responsible for the residence and tower.
The views along the byway include red rock canyons and cliffs, golden sandstone areas, forests, and broad sweeping views of the four corners region. The route is paved with passing lanes on the steeper hills. The beginning 10 miles of the rounte is a narrower two lane paved road requiring some caution on the turns with larger vehicles and trailers. The remainder is wide with passing and turning lanes.